Donovan's Brain (1953)
Directed by Felix E. Feist
A scientist takes the brain of dead man and revives it via electrodes as it lays suspended in a tank of liquid. Soon, the brain grows to possess enormous psychic powers and inflicts its personality upon the doctor who saved it, creating a "Jekyll and Hyde" paradigm.
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What critics compared Donovan's Brain to
He has been injecting Mayan medicine into the tumorous brain of a monkey named Donovan (a tribute to the 1953 surgical science-fiction movie Donovan's Brain) to find a cure for the cancer that threatens the life of his novelist wife Izzy, played by Weisz.
Example: "At the end of [ Donovan's Brain ], the scientist attacks [a tank filled with a disembodied psychic brain] with an ax, resisting the endless undertow of Donovan's will by reciting a simple yet haunting mnemonic phrase— He thrusts his fists against the posts and still insists he sees the ghosts ."
Disembodied brains as a sci-fi staple range from the shrewdly effective "Donovan's Brain" to the famously idiotic "They Saved Hitler's Brain."