With a title like The 40 Year Old Virgin (and with a marketing campaign that borders on genius), you know that, as with other "losin' it" pictures (Losin' It, Revenge of the Nerds , Hardbodies, The Last American Virgin , and on and on), the hero's going to get laid--most often to a fireworks accompaniment (or selections from Hair, as the case may be).
As if casting themselves in the belated sequel to Losin' It, Andy's flabbergasted colleagues become the architects of a sacred quest for nooky, which variously entails locking Andy in the store overnight while porn plays on all screens, waxing his chest hair, and tutoring him in the dark art of the pickup line; stoner Jedi master Cal (Rogen) at one point intones that oft forgotten command from the Zen handbook, "Be David Caruso in Jade," a bidding that Andy grasps with an instinctual, even mystical authority.